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Observed genes
Polygenic score
Influential genes: NCAM1
The gene NCAM1 has been associated with Gastroesophageal reflux disease in a GWAS study.
About Gastroesophageal reflux disease (GERD)
Gastroesophageal reflux disease (GERD) is characterized by stomach contents flowing back into the food pipe (esophagus). The underlying cause is not always clear but can include incomplete closing of the lower esophageal sphincter or specific food and drink habits. Most people feel this as a burning sensation behind their chest wall (heartburn) or acidic taste in their mouth in the morning.
Why should I treat this condition?
Besides uncomfortable symptoms like heartburn, acidic mouth taste, cough, or difficulties swallowing, the backwash can irritate and damage tissue. Over years without treatment, it can cause it to transform into precancerous lesions or even cancer.
Recommendations
Most people can manage GERD without the need for medical intervention through simple lifestyle modifications. Avoid lying down directly after eating. Reduce your consumption of coffee, alcohol, and food triggering your symptoms, as well as stick to having light meals and small portions.
Recommendations
Most people can manage GERD without the need for medical intervention through simple lifestyle modifications. Avoid lying down directly after eating. Reduce your consumption of coffee, alcohol, and food triggering your symptoms, as well as stick to having light meals and small portions.
